FOXO4-DRI (10mg)

Buy FOXO4-DRI UK | Proxofim Senolytic Peptide

Buy FOXO4-DRI UK (Proxofim), a high-purity synthetic research peptide supplied by Peptide House UK strictly for laboratory use. Researchers actively use this compound because it originates from the FOXO4 transcription factor and targets key senescence-related signalling pathways.

Importantly, scientists engineered FOXO4-DRI using a D-retro-inverso (DRI) structure. As a result, the peptide demonstrates improved enzymatic stability compared to natural peptide sequences. Therefore, researchers prefer it in controlled experimental environments where consistency is essential.

Why Researchers Use FOXO4-DRI

Researchers choose FOXO4-DRI because it provides a focused model for studying cellular ageing and senescence. In particular, it helps scientists examine how p53 signalling behaves when FOXO4 interactions change. Moreover, this makes it highly relevant in longevity and senolytic research.

Additionally, FOXO4-DRI plays an important role in experimental systems that explore how senescent cells accumulate over time. Consequently, researchers investigate how removing these cells may improve tissue function and biological resilience.

• Senescent cell clearance studies
• p53 pathway activation research
• Cellular ageing models
• Tissue regeneration investigations
• Inflammation reduction pathway studies

Mechanism of Action

FOXO4-DRI works by disrupting the interaction between FOXO4 and the p53 protein. When this interaction weakens, p53 may regain its ability to initiate apoptosis in senescent cells.

As a result, researchers observe increased interest in this compound within senolytic studies. Furthermore, senescent cells normally resist apoptosis, so their accumulation contributes to inflammation and tissue dysfunction over time.

Therefore, FOXO4-DRI is widely studied as a tool to explore targeted cellular removal strategies in ageing models.

• Restores apoptosis signalling in damaged cells
• Targets senescent cell survival pathways
• Modulates FOXO–p53 protein interaction
• Supports cellular turnover research models

Key Research Applications

1. Senescent Cell Clearance Research

Researchers use FOXO4-DRI to study how aged or damaged cells can be selectively removed from biological systems. In many models, this process leads to improved tissue performance.

In addition, studies often show reduced inflammatory signalling after senescent cell reduction, which further supports its relevance in senolytic research.

• Selective senescent cell removal
• Reduced inflammatory markers
• Enhanced cellular renewal

2. Longevity & Ageing Research

FOXO4-DRI is widely used in longevity studies because it targets one of the core mechanisms of ageing biology. Specifically, researchers focus on how senescent cells accumulate and affect tissue performance.

Moreover, scientists investigate whether reducing these cells may improve biological resilience over time.

• Longevity pathway modulation
• Tissue function preservation models
• Age-related decline studies

3. Tissue Function & Regeneration

Researchers also study FOXO4-DRI in tissue regeneration models. When senescent cells decrease, biological systems often show improved recovery responses.

Therefore, scientists use this peptide to better understand how cellular turnover affects tissue repair mechanisms.

• Tissue regeneration research
• Cellular turnover studies
• Functional recovery models

4. Metabolic & Stress Response Research

FOXO proteins play a central role in metabolic regulation. For this reason, researchers study FOXO4-DRI in insulin and IGF-related pathways that control cellular energy balance.

Additionally, these pathways help scientists understand how ageing affects metabolic stability and stress response systems.

• Metabolic signalling studies
• Cellular stress response research
• Insulin pathway analysis

5. Oxidative Stress Research

FOXO proteins also regulate antioxidant defence systems. Consequently, FOXO4-DRI is used in oxidative stress models to evaluate how senescent cells respond to cellular damage.

Furthermore, researchers study how these responses change under ageing-related conditions.

• Oxidative stress response studies
• Antioxidant pathway research
• Cellular defence mechanism models

Chemical Profile

• Molecular Formula: C228H388N86O64
• Molecular Weight: 5358.05 g/mol
• Other Names: Proxofim, FOXO4a, AFX, MLLT7

Why Choose Peptide House UK?

• High-purity research compounds
• Strict laboratory-grade quality control
• Fast and secure UK shipping
• Trusted peptide supplier
• Consistent batch reliability

Important Notice

FOXO4-DRI is supplied strictly for laboratory research purposes only. It is not intended for human consumption, medical use, or diagnostic applications.

At Peptide House UK, we ensure strict research-grade handling standards. Therefore, researchers receive consistent and reliable compounds for controlled scientific studies.